منابع مشابه
The GH/IGF-I axis and longevity.
Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned out to be orthologues of the mammalian genes encoding insulin-like signalling...
متن کاملThe GH/IGF-1 Axis and Heart Failure
The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis regulates cardiac growth, stimulates myocardial contractility and influences the vascular system. The GH/IGF-1 axis controls intrinsic cardiac contractility by enhancing the intracellular calcium availability and regulating expression of contractile proteins; stimulates cardiac growth, by increasing protein synthesis; modifies sy...
متن کاملThe GH/IGF-1-Axis in Psychopathological Functions
Alterations of the somatotropic system as seen in Growth Hormone Deficiency (GHD) or acromegaly can lead to a variety of mental and physical impairments. Especially the prevalence of psychiatric disorders is elevated and cognitive function is impaired. These changes are paralleled by disturbances of the macroscopic brain tissue architecture and may persist despite achievement of biochemical con...
متن کاملInsulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response to the diabetic milieu. A significant reduction of serum IGF-I levels was observed in patients with type 1 diabetes mellitus (T1DM). Inversely...
متن کاملThe role of the IGF axis in IGFBP-1 and IGF-I induced renal enlargement in Snell dwarf mice.
Insulin-like growth factor (IGF) binding protein-1 (IGFBP-1) is generally believed to inhibit IGF action in the circulation. In contrast, IGFBP-1 has been reported to interact with cell surfaces and enhance IGF-I action locally in some tissues. Renal IGFBP-1 levels are found elevated in various conditions characterized by renal growth (e.g. diabetes mellitus, hypokalemia). To test whether IGFBP...
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ژورنال
عنوان ژورنال: Molecular Pathology
سال: 2001
ISSN: 1366-8714
DOI: 10.1136/mp.54.3.138